Selexis helps Lubris to produce cost effectively

Selexis SA, a global life sciences company for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins, announced today that its US-based customer, Lubris LLC, has achieved over 1 g/L per liter yield in manufacturing production runs of LUB-13-04 as measured by Lubris’ CMO partner. “The results from the Selexis/Lubris partnership are quite impressive," said Igor Fisch, PhD, CEO of Selexis SA. “We continue to demonstrate that the SUREtechnology Platform™ has a major impact on the economics of manufacturing biologics by significantly increasing the manufacturing cell line’s stability and productivity.”

“Recombinant lubricin has been proven to be difficult to express efficiently at levels that ensured commercial viability. This is the first reported case of expression levels exceeding 1 g/L for lubricin (or lubricin-like proteins). We chose Selexis based on its track record for overcoming expression bottlenecks with difficult-to-express proteins, and generating fully documented cell lines used for clinical manufacturing,” said Ed Truitt, CEO of Lubris. “These results represent a major development milestone as they demonstrate that our technology can be manufactured cost effectively in an increasingly challenging economic environment. We are on schedule to begin clinical trials in 2013 with our Swiss based European partner with our treatment for dry eye disease which represents a significant unmet medical need in a multi-billion dollar ophthalmic market.”